Well he did already have a run at it. Maybe we are getting lucky and he might lose, go away, and just be a skidmark on history instead of a complete shit pants situation. I’m choosing to believe the time travelers who stopped the assassination attempts from succeeding are just making sure we have skid marks instead of shit pants.
It’s just about playing the character as the persons’ own gender identity. Most common, of course, being video game characters as opposite genders. So like, lady master chief or what if zelda was a man, etc. But I’ve seen an androgynous/enby kratos that was super well done! Gender-bent / gender-bending is just the term that has stuck for that.